The latest American Journal of Veterinary Research arrived at catmanager’s office the other day. The issue (Vol. 63, No. 3) is available online here. Of note in the new issue:

  • A study (246–250; abstract here) of buprenorphine’s effects on horses finds (as with other opioids) a significant excitatory response to doses at 5 μg/kg and 10 μg/kg but an analgesic effect at only the higher dose.
  • A study (258–264; abstract here) of the long-term (90 days) oral use in dogs of five NSAIDs finds only minor changes “in hemostatic and serum biochemical variables” for each studied drug. The study did find variability in the frequency of adverse gastrointestinal effects, with carprofen causing the fewest, followed by meloxicam. The authors recommend periodic monitoring of dogs on long-term NSAID administration with CBC, serum chemistry, and endoscopy.
  • A controlled study (290–296; abstract here) finds autologous conditioned serum (ACS) beneficial in the treatment of horses with osteoarthritis. The authors caution that further studies, including clinical trials, are necessary to confirm the finding and determine ACS’s mechanisms of action.
  • A study (313–322; abstract here) finds that bethanechol might benefit cows with motitility disorders.